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Do calorie-free sweeteners cause appetite disruption?

A new study from the Keck School of Medicine at the University of Southern California reveals that calorie-free sweeteners, like sucralose, can disrupt brain signals related to appetite and potentially increase cravings, particularly in people with obesity. Published in Nature Metabolism, the study shows sucralose activates the hypothalamus, a region of the brain that helps regulate hunger and body weight. While it mimics the sweetness of sugar, sucralose does not provide the expected caloric energy. This mismatch may lead to an increase in appetite and overeating, especially over time.

San Bernardino operation makes progress to combat violence and theft

FDA crackdown on 'poppers' triggers supply rush

Local|Health

What are 'poppers' and why is the FDA cracking down on them?

Alkyl nitrites – commonly known as “poppers” – have a complex regulatory history dating back to the 19th century, when amyl nitrites were used as medical treatments for chest pain and asthma. According to a 2024 paper in the California Law Review, these substances were available over the counter during the 1960s before being restricted to prescription use after gay nurses helped popularize recreational applications. As amyl nitrite gave way to other alkyl nitrite formulations, the products maintained popularity in clubs during the 1970s. By the 1980s, use became largely concentrate

4 killed, 2 injured in Santa Ana crash, including 2 sets of sisters

Newsom announces plan to support Californians with developmental disabilities

Lifestyle|Local|News|WrittenByLAPost

“Nurse Hailey,” nursing influencer, passes away in childbirth after amniotic fluid embolism

Hailey Okula, a Los Angeles-based nurse who operated a popular Instagram account posting videos about life in her profession, has passed away, her husband Matt Okula announced Wednesday. “It is with the heaviest of heart that I share the devastating news of the unexpected passing of my beautiful wife, Hailey Marie Okula, due to complications from childbirth,” Matt said in a post on Hailey’s page. The couple’s child, Crew, was delivered successfully and is in good health. In an interview with Fox 11, Matt reported that Hailey died of cardiac arrest following an amniotic fluid

Amazon makes a last-minute bid to buy TikTok as deadline looms

Trump's 25% tariff on imported cars raises concerns industry leaders

US News

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Celebrity|Crime|Entertainment|US

‘The most powerful type of liar’: Tapper asks Anna Delvey how she views her criminal past

What is it about Anna Delvey that fascinates so many people? Including your humble crew at United States of Scandal? Why has she captured so many column inches in newspapers and pages in magazines, filled so many hours of footage in podcasts, Netflix dramatizations, and news broadcasts? From her false identity as a German heiress to financial deception, grand larceny, serving time at Rikers, competing on Dancing with the Stars, and now pursuing a career in fashion, Anna’s journey has been nothing short of fascinating.Having met and interviewed her in 2022, I still can’t quite figure her ou

Environment|US

Tornadoes, heavy rains rip across central, southern US

Tornadoes ripped across a wide swath of central and southern United States on Wednesday, destroying homes and businesses and bringing down power lines and trees.The National Weather Service said there had been at least 15 reports of tornadoes in at least four states by late Wednesday. Eight people have been injured across Kentucky and Arkansas, including one critically injured in Kentucky's Ballard County, local officials said.Late Wednesday, Arkansas Governor Sarah Huckabee Sanders declared a state of emergency across the state due to the storms, which also brought hail and torrential ra

Attorneys for Tufts University student accuse government of ‘secretive’ effort to move her across state lines

World leaders react to Trump's tariffs

Health|Science|US

Two infants die of whooping cough in Louisiana as cases climb nationally

In his 20 years working in pediatric infectious disease, Dr. John Schieffelin has never seen another illness like pertussis.Also known as whooping cough, it’s a contagious respiratory illness that can develop into a painful, full-body cough. The coughing fits can be severe, often accompanied by a whooping sound when the person tries to catch their breath. And it’s continuous, even if a person needs to be placed on a ventilator, says Schieffelin, an associate professor of pediatrics at Tulane University.“For infants, it’s really rather terrifying,” he said. “They’re just coughing

Business|Crime|Technology|US

Man faces charges after Teslas set on fire with Molotov cocktails

Tesla sales plunged 13% in the first three months of this year, the largest drop in deliveries in its history, as backlash against CEO Elon Musk and growing competition took a large bite out of demand for its EVs.Tesla reported Wednesday that it delivered 336,681 cars in the quarter, 50,000 fewer vehicles compared to the first three months of last year. The results were the company’s worst sales in nearly three years.Tesla has faced protests outside its showrooms from those opposed to the actions of Musk in one of his other roles as the head of the Department of Government Efficiency, and th

Timberwolves sale to Alex Rodriguez and Marc Lore will go forward, AP source says

Mass shooter who killed 6 people at The Covenant School had no grudge against victims but was fueled by a quest for notoriety

World News

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MidEast|Political|World

Israel to seize parts of Gaza as military operation expands

Israel announced a major expansion of military operations in Gaza on Wednesday, saying large areas of the enclave would be seized and added to its security zones, accompanied by large-scale evacuations of the population.Prime Minister Benjamin Netanyahu said troops were seizing an area he called the Morag Axis, a reference to a former Israeli settlement once located between the cities of Rafah and Khan Younis in the south of the Gaza Strip, some 3-4 kilometres from the southern border."Because we are now dividing the Strip and we are increasing pressure step by step so they will give us our ho

World leaders react to Trump's tariffs

U.S. President Donald Trump said he would impose a 10% baseline tariff on all imports to the United States and higher duties on some of the country's biggest trading partners, drawing defiant responses from leaders and governments. Trump is not imposing his new 10% global tariff rate on goods from top trading partners Canada and Mexico while his previous order remains in place for up to 25% tariffs on many goods from the two countries.Here are some reactions from top officials and governments around the world:EUROPEAN COMMISSION PRESIDENT URSULA VON DER LEYEN"President Trump's announcement of

A wary Europe awaits Rubio with NATO's future on the line

The Taliban senses an opening as it pushes for diplomatic recognition in talks with Trump administration

Counting the potential toll of Trump's tariffs on major Asian economies

The trade war that U.S. President Donald Trump has escalated in his second term is a challenge for all Asian economies, large and small, in an era when the most populous region of the world is expected to drive global economic growth. Export manufacturing and free trade helped transform China and other Asian countries into economic powerhouses over the past decades. Trump’s barrages of tariffs, aimed at compelling companies to keep or set up their factories in the United States, are rupturing trade agreements often made at great political cost to trading partners.

Europe|Political|World

Putin calls up 160,000 men to Russian army in latest conscription drive, at crucial moment in Ukraine war

One of the largest rounds of conscription to Russia’s military for several years is underway, as President Vladimir Putin pushes ahead with an expansion of the country’s military at a crucial moment in the war in Ukraine.Putin signed a decree authorizing the latest phase of the country’s twice-yearly conscription effort, with the new window beginning Tuesday and running until July 15.It will see 160,000 men between 18 and 30 join Russia’s armed forces – an increase of 10,000 on last year’s spring drive, and a rise of more than 15,000 compared to three years ago, according to Russia

Europe will respond proportionately to likely Trump tariffs, French industry minister says

Middle East latest: Israel is establishing a new military corridor across Gaza

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Economy|Political|Travel|US

Canadian couple cancels tens of thousands in travel to the US

Americas|Political|US

Attorney for father deported in 'error' says this is what's 'new, unique and terrifying' about case

CNN's Erin Burnett speaks with Simon Sandoval-Moshenberg, the attorney for a Maryland father the Trump administration conceded it mistakenly deported to El Salvador “because of an administrative error.”

Education|Political|US

Exclusive: Secretary of Education explains what department will do after Trump begins dismantling it

Secretary of Education Linda McMahon outlines what she expects the Department of Education will do now following President Donald Trump's executive order that began the process of dismantling the department.

Political|US

Former federal judge says Trump is playing a 'dangerous game' with Judge Boasberg

Business|Economy|Political|Travel|US

Canadians to Maine: No, thanks!

Canadian tourists make up about 30-40% of the revenue for many businesses in Old Orchard Beach, Maine. This year, many are choosing to skip their regular getaway, given President Trump’s antagonistic rhetoric towards Canada. The owner of the Point of View Inn tells CNN’s Randi Kaye he’s had so many cancellations that his business may not survive.