(CNN) โ Sen. Mitch McConnell was a generational force for the Republican Party โ using procedural tactics and political will to stymie much of former President Barack Obamaโs agenda, hand President Donald Trump key first-term political victories and deliver a 6-3 conservative Supreme Court majority.
Now heโs the odd man out.
Weeks after relinquishing his leadership post as a new GOP majority was sworn into office, McConnell finds himself, likely in the final stage of his career, untethered from the party heโd led, in turns as minority and majority leader, since 2007.

He has cast a trio of votes against Trumpโs Cabinet nominees โ putting him at odds with nearly all Senate Republicans. He opposed Pete Hegseth for defense secretary, citing the former Fox News hostโs lack of experience and clear vision for how to counter Chinaโs aggression toward Taiwan. He was the sole GOP vote against Tulsi Gabbard for director of national intelligence, criticizing the former Hawaii Democratic congresswomanโs โhistory of alarming lapses in judgment.โ
And on Thursday, McConnell, a childhood polio survivor, cast the only Republican vote against Robert F. Kennedy Jr. to lead the Department of Health and Human Services, saying Kennedy โfailed to prove he is the best possible person to lead Americaโs health agency.โ
McConnell has also publicly lamented the GOPโs Trump-fueled drift away from positions that he still holds dear โ in support of free trade and a muscular foreign policy.
โHe is eager to demonstrate he has an independent streak and some deep convictions that he could not always reveal as a majority leader,โ said Indiana Sen. Todd Young, a Republican. โHeโs liberated.โ

McConnellโs votes against Trumpโs nominees come amid a challenging chapter for his health. The senator, who suffered falls earlier this month that left him injured, is now using a wheelchair, sometimes isolating him from fellow senators on the floor. CNN has observed on occasion that McConnell will sit in a private hallway just off the floor in between votes, a stark departure from when he was leader and a flurry of members would surround him and vie for his attention.
Colleagues say McConnell, who turns 83 on February 20 and has nearly two full years remaining in his term, is embracing his new role, free of the job managing an ideologically fractured conference and instead on a mission to trumpet his view that the United States cannot turn away from its role in the world.
โThere are recognized responsibilities when you are in leadership โ and particularly when you are the leader, as he has been for 18 years. I think you have to give up on the freedom a little bit to act as your own person because you have a responsibility to speak for your full conference,โ said Alaska Sen. Lisa Murkowski, a Republican who also voted against Hegseth in January. โAnd I think you are seeing him now as a stand-alone legislator and happy.โ
Drawing Trumpโs ire
As he opposed three Trump nominees, McConnell has been careful not to blindside his partyโs Senate leadership, aware of the responsibilities that come with those roles and not long removed from the memories of what it was to lead an at times split party.
McConnellโs votes against Trumpโs nominees havenโt bothered fellow Senate Republicans, including the partyโs new Majority Leader, South Dakota Sen. John Thune, who said McConnell has warned him and the partyโs whip, Wyoming Sen. John Barrasso, ahead of time.
โThose werenโt surprises,โ Thune told CNN on Thursday. โHeโs been clear with us where he isโ on Trumpโs nominees.
While few have said so publicly, some Senate Republicans are frustrated with one aspect of McConnellโs independent streak.
โOne of the things that disappoints me the most is Thune stood with Mitch for two decades and was extremely loyal to him and when Mitch had a play call, Thune followed it sometimes at his detriment,โ said Oklahoma Sen. Markwayne Mullin. โI donโt see that favor being returned here.โ
And Trump is lashing out at McConnell.
In the Oval Office on Thursday following McConnellโs vote against confirming Kennedy, Trump told CNN that McConnell is โnot equipped mentally,โ said he feels sorry for the senator and claimed McConnell had not been ready to give up his leadership post.
โHe wasnโt equipped 10 years ago, mentally, in my opinion. He let the Republican Party go to hell,โ Trump said. โIf I didnโt come along, the Republican Party wouldnโt even exist right now.โ
The president said McConnell โnever really had it,โ and said his fundraising acumen was โbecause of his position as leader, which anybody could do.โ
And in an extraordinary moment, Trump seemed to suggest McConnell โ a childhood polio survivor who cited Kennedyโs longstanding criticism of vaccines as a reason for his vote against his confirmation as health and human services secretary โ may not have had polio at all.
โI have no idea if he had polio,โ Trump said. โAll I can tell you about him is said he shouldnโt have been leader. He knows that. He voted against Bobby. He votes against almost everything. Now heโs a very bitter guy, and we have a very strong party, and heโs almost โ not even really a very powerful member. Letโs say heโs lost his power, and itโs affected his vote.โ
Though McConnell, a seven-term senator, has not yet announced his retirement, Republicans in his home state are already lining up for whatโs expected to be a competitive 2026 primary to fill his seat. And in that raceโs earliest stages, major contenders are all running toward Trump and away from McConnell.
The presidentโs son, Donald Trump Jr., previewed how Trump-world sees the potential race to replace McConnell, citing one potential candidateโs shot at McConnell and writing this week on X: โIf youโre running for office, especially in Kentucky, and you want my support, donโt even bother reaching out to me unless youโre willing to publicly oppose Mitch McConnell like this.โ
From McConnellโs vantage point, the view of Trumpโs presidency and their relationship is much different. Though McConnell has criticized Trump at times, he has also said he wants him to succeed as president โ and he has largely voted with Trump, including on more than a dozen other nominees.
A foreign policy divide
The end of McConnellโs tenure as the longest-serving leader in Senate history โ and the decline of his influence in both the Republican Party and the institution of the Senate โ is a window into a party that is rapidly evolving.
Trump has campaigned and governed in support of steep, inflation-inducing tariffs, slashing foreign aid and withdrawing the United States from global pacts. McConnell has pushed back on all three fronts.
โIn Washington, as we face down a new era of great power competition, influential voices want to leave the lessons of the last such competition, the Cold War, at the door,โ McConnell warned at the Reagan Defense Forum in December.
McConnellโs desire for an active US role in deterring aggression from Russia in Ukraine and China in Taiwan, though, has put him at odds with a growing share of the Republican electorate, which has embraced Trumpโs more isolationist view.
Still, McConnellโs positions are in line with much of the Senate GOP, which Missouri Sen. Josh Hawley said is โstill a caucus that is full of a lot of traditionalists.โ
โHe probably speaks for a lot of people. At least that is my sense,โ said Hawley, who does not share many of McConnellโs views.
As chairman of the Senate Appropriations Committeeโs defense subcommittee, McConnell holds a post that has broad power in determining the investments the United States makes in its own military and across the globe.
He also chairs the Senate Rules Committee, which has broad jurisdiction on issues related to election security and Senate procedure like preserving the filibuster, the rule that requires most legislation be subject to a 60-vote threshold โ something McConnell has ardently defended and Trump has urged his party to jettison.
He criticized Trumpโs announcement of sweeping tariffs that will force US businesses to pay new taxes on goods imported from China, Canada and Mexico, as well as imports of aluminum and steel, in an op-ed in his hometown Louisville Courier-Journal.
โTrade wars with our partners hurt working people most. And the president has better tools to protect American workers without forcing our families and businesses to absorb higher costs,โ McConnell wrote in the opinion piece, which was published Wednesday.
Strange bedfellows
Now out of power across all three branches of the federal government, Democrats who have long criticized McConnell are praising his independent streak.
Virginia Sen. Tim Kaine said McConnell is โvoting his conscience, and heโs not afraid of anybody.โ
He said McConnell is casting votes that many of his GOP colleagues agree with: โThey have deep concerns, but they are afraid. They are afraid of MAGA minions being unleashed against them.โ
โMitch McConnell isnโt afraid of anybody or anything right now, which is a great thing,โ Kaine said.
However, outside the confines of the Senate, many Democrats argue that McConnell played an enormous role in leading to this moment: Trump in a second term as president, with very few checks on his power.
They blame McConnellโs use of the filibuster for fracturing Washington and remain angry with his decision to block a vote on Obamaโs Supreme Court nominee for nearly a year to keep that seat open for Trump to fill โ an unprecedented and bare-knuckled move that guaranteed a long-standing conservative majority.
McConnell, they point out, could have backed the Democratic effort to impeach Trump after the January 6, 2021, attack on the Capitol โ a moment that led McConnellโs wife, Elaine Chao, to step down as Trumpโs transportation secretary. If Trump had been convicted, the Senate could have also made him ineligible to run for president again.
โAs a Christian, I believe in redemption,โ former Florida Rep. Val Demings said on X. โBut the Senatorโs critical chance has passed. America could have avoided this madness with a little courage during the 1st and 2nd impeachments. Principle matters all the time.โ
Instead, McConnell led Senate Republicans as they refused to convict Trump. He then endorsed Trump โ who had lobbed racist insults at his wife and referred to him as โOld Crowโ โ in March 2024, when it became clear that Trump would be the GOPโs presidential nominee.
Asked if McConnellโs votes against Trump could change those long-standing Democratic views of him, Kaine said: โI am not really thinking about it that way.โ
CNNโs Ted Barrett, DJ Judd and Kaitlan Collins contributed to this report.
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